DRUG TREATMENT - Opioids - General Info Drug Rotation
Managing Refractory Pain or Opioid Toxicity—Drug Rotation
Titration—Reduce first opioid by 1/3 each day, while starting second opioid, titrating up over 3 days to target starting dose, which should be at much lower morphine equi-analgesic dose (25-50% lower)
When sedation occurs—problem of incomplete cross-tolerance due to inter-patient variability
